Exposed and Sequestered Antigens in Testes and Their Protection by Regulatory T Cell-Dependent Systemic Tolerance
Continuous exposure of tissue antigen (Ag) to the autoantigen-specific regulatory T cells (Treg) is required to maintain Treg-dependent systemic tolerance.Thus, testis autoantigens, previously considered as sequestered, may not be protected by systemic tolerance.We now document that the complete testis antigen sequestration is not valid.The haploid